3 papers
cs.CV2024
Image segmentation of treated and untreated tumor spheroids by Fully Convolutional Networks
Matthias Streller, Soňa Michlíková, Willy Ciecior +4
Multicellular tumor spheroids (MCTS) are advanced cell culture systems for assessing the impact of combinatorial radio(chemo)therapy. They exhibit therapeutically relevant in-vivo-…
physics.bio-ph2024
Generalized, sublethal damage-based mathematical approach for improved modeling of clonogenic survival curve flattening upon hyperthermia, radiotherapy, and beyond
Adriana M. De Mendoza, Soňa Michlíková, Paula S. Castro +4
Mathematical modeling can offer valuable insights into the behavior of biological systems upon treatment. Different mathematical models have been designed to predict the efficacy o…
physics.bio-ph2020
Mathematical model for the thermal enhancement of radiation response: Thermodynamic approach
Adriana M. De Mendoza, Soňa Michlíková, Johann Berger +3
Radiotherapy can effectively kill malignant cells, but the doses required to cure cancer patients may inflict severe collateral damage to adjacent healthy tissues. Hyperthermia (HT…