2 papers
stat.ME2020
Statistical design considerations for trials that study multiple indications
Alexander M. Kaizer, Joseph S. Koopmeiners, Nan Chen +1
Breakthroughs in cancer biology have defined new research programs emphasizing the development of therapies that target specific pathways in tumor cells. Innovations in clinical tr…
stat.CO2019
Analyzing Basket Trials under Multisource Exchangeability Assumptions
Michael J. Kane, Nan Chen, Alexander M. Kaizer +3
Basket designs are prospective clinical trials that are devised with the hypothesis that the presence of selected molecular features determine a patient's subsequent response to a…