64 citations · 79 across the 12 of their papers we have counts for
4 papers · 1 filter
Design and Analysis of group-sequential clinical trials based on a modestly-weighted log-rank test in anticipation of a delayed separation of survival curves: A practical guidance
Dominic Magirr, José L. Jiménez
A common feature of many recent trials evaluating the effects of immunotherapy on survival is that non-proportional hazards can be anticipated at the design stage. This raises the…
Non-proportional hazards in immuno-oncology: is an old perspective needed?
Dominic Magirr
A fundamental concept in two-arm non-parametric survival analysis is the comparison of observed versus expected numbers of events on one of the treatment arms (the choice of which…
Modestly Weighted Logrank Tests
Dominic Magirr, Carl-Fredrik Burman
We propose a new class of weighted logrank tests (WLRT) that control the risk of concluding that a new drug is more efficacious than standard of care, when, in fact, it is uniforml…
Adaptive Survival Trials
Dominic Magirr, Thomas Jaki, Franz Koenig +1
Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error rates are controlled.…