21 citations · 27 across the 11 of their papers we have counts for
12 papers
Measurements of the micro-spill structure of medical cyclotron and synchrotron beams and its impact on pulse pileup
Matthias Knopf, Simon Waid, Stefan Gundacker +10
Detector characterization and instrumentation testing are often performed at cyclotron and synchrotron facilities, many of which were originally developed for medical applications…
Mechanistic driven TCP and NTCP modeling for particle therapy accounting for a broad range of physical irradiation parameters and tissue environmental conditions
Marco Battestini, Jules Morand, Giulio Bordieri +3
In conventional radiotherapy, the probability of controlling tumor growth is quantified using Tumor Control Probability (TCP) models. Instead, the probability of experiencing a sid…
A stochastic agent-based extension of the GSM2 model for particle therapy: cell-cycle dynamics, dose-rate dependence, and fractionation effects
Francesco G. Cordoni, Marco Battestini, Marta Missiaggia
Accurately linking microscopic energy deposition from ionizing radiation to emergent biological outcomes remains a central challenge in radiobiological modelling, particularly when…
One scale to rule them all: interpretable multi-scale Deep Learning for predicting cell survival after proton and carbon ion irradiation
Giulio Bordieri, Giorgio Cartechini, Anna Bianchi +4
The relationship between the physical characteristics of the radiation field and biological damage is central to both radiotherapy and radioprotection, yet the link between spatial…
A combined dose and microdosimetric modeling framework incorporating volume effects correlates with tissue sparing in proton minibeam radiotherapy
Giulio Bordieri, Marco Battestini, Gianluca Lattanzi +4
Proton minibeam (pMB) radiotherapy, delivers highly heterogeneous dose distributions alternating high-dose peaks and low-dose valleys. This aims to widen the therapeutic window by…
Machine Learning-based beam delivery time model for Mevion 250i with Hyperscan technology
Giorgio Cartechini, Francesco Giuseppe Cordoni, Mirko Unipan +1
Purpose: Accurate prediction of beam delivery time (BDT) is essential for operational efficiency, 4D dose calculations, and advanced proton therapy techniques. Despite its importan…
Integrating nano- and micrometer-scale energy deposition models for mechanistic prediction of radiation-induced DNA damage and cell survival
Giulio Bordieri, Marta Missiaggia, Gianluca Lattanzi +3
We present an integrated modeling framework that combines the Generalized Stochastic Microdosimetric Model (GSM2), used to predict cell survival fractions, with MINAS-TIRITH, a fas…
Hallucination Detection in LLMs with Topological Divergence on Attention Graphs
Alexandra Bazarova, Andrei Volodichev, Aleksandr Yugay +10
Hallucination, i.e., generating factually incorrect content, remains a critical challenge for large language models (LLMs). We introduce TOHA, a TOpology-based HAllucination detect…
A multiscale radiation biophysical stochastic model describing the cell survival response at ultra-high dose rate
Marco Battestini, Marta Missiaggia, Sara Bolzoni +2
Ultra-high dose-rate (UHDR) radiotherapy, characterized by an extremely high radiation delivery rate, represents one of the most recent and promising frontier in radiotherapy. UHDR…
The Generalized Stochastic Microdosimetric Model: the main formulation
F. Cordoni, M. Missiaggia, A. Attili +3
The present work introduces a rigorous stochastic model, named Generalized Stochastic Microdosimetric Model (GSM2), to describe biological damage induced by ionizing radiation. Sta…
A novel hybrid microdosimeter for radiation field characterization based on TEPC detector and LGADs tracker: a feasibility study
M. Missiaggia, E. Pierobon, M. Castelluzzo +11
In microdosimetry, lineal energies y are calculated from energy depositions inside the microdosimeter divided by the mean chord length, whose value is based on geometrical assu…
Linking microdosimetric measurements to biological effectiveness: a review of theoretical aspects of MKM and other models
V. E. Bellinzona, F. Cordoni, M. Missiaggia +4
Different qualities of radiation are known to cause different biological effects at the same absorbed dose. Enhancements of the biological effectiveness are a direct consequence of…