155 citations · 469 across the 40 of their papers we have counts for
40 papers
Anti-seizure medication load is not correlated with early termination of seizure spread
Nathan Evans, Sarah J. Gascoigne, Guillermo M. Besne +11
Objective: Anti-seizure medications (ASMs) are the mainstay of treatment for epilepsy, yet their effect on seizure spread is not fully understood. Higher ASM doses have been associ…
Anti-seizure medication tapering correlates with daytime delta band power reduction in the cortex
Guillermo M. Besne, Nathan Evans, Mariella Panagiotopoulou +11
Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, des…
Alpha rhythm slowing in temporal epilepsy across Scalp EEG and MEG
Vytene Janiukstyte, Csaba Kozma, Thomas W. Owen +8
EEG slowing is reported in various neurological disorders including Alzheimer's, Parkinson's and Epilepsy. Here, we investigate alpha rhythm slowing in individuals with refractory…
Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain
Heather Woodhouse, Gerard Hall, Callum Simpson +18
Background: Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) fr…
Incomplete resection of the icEEG seizure onset zone is not associated with post-surgical outcomes
Sarah J. Gascoigne, Nathan Evans, Gerard Hall +16
Delineation of seizure onset regions from EEG is important for effective surgical workup. However, it is unknown if their complete resection is required for seizure freedom, or in…
Aperiodic MEG abnormality in patients with focal to bilateral tonic-clonic seizures
Kirandeep Kaur, Jonathan J Horsley, Csaba Kozma +7
Aperiodic activity is a physiologically distinct component of the electrophysiological power spectrum. It is suggested to reflect the balance of excitation and inhibition in the br…
Identifying epileptogenic abnormality by decomposing intracranial EEG and MEG power spectra
Csaba Kozma, Gabrielle Schroeder, Tom Owen +6
Identifying abnormal electroencephalographic activity is crucial in diagnosis and treatment of epilepsy. Recent studies showed that decomposing brain activity into periodic (oscill…
Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo
Christopher Thornton, Mariella Panagiotopoulou, Fahmida A Chowdhury +10
Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expressio…
Interictal MEG abnormalities to guide intracranial electrode implantation and predict surgical outcome
Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall +9
Intracranial EEG (iEEG) is the gold standard technique for epileptogenic zone (EZ) localisation, but requires a hypothesis of which tissue is epileptogenic, guided by qualitative a…
Identifying epileptogenic abnormalities through spatial clustering of MEG interictal band power
Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall +8
Successful epilepsy surgery depends on localising and resecting cerebral abnormalities and networks that generate seizures. Abnormalities, however, may be widely distributed across…
Normative brain mapping using scalp EEG and potential clinical application
Vytene Janiukstyte, Thomas W Owen, Umair J Chaudhary +6
A normative electrographic activity map could be a powerful resource to understand normal brain function and identify abnormal activity. Here, we present a normative brain map usin…
Complementary structural and functional abnormalities to localise epileptogenic tissue
Jonathan J Horsley, Rhys H Thomas, Fahmida A Chowdhury +10
When investigating suitability for surgery, people with drug-refractory focal epilepsy may have intracranial EEG (iEEG) electrodes implanted to localise seizure onset. Diffusion-we…
Temporal stability of intracranial EEG abnormality maps for localising epileptogenic tissue
Yujiang Wang, Gabrielle M Schroeder, Jonathan J Horsley +8
Objective: Identifying abnormalities in interictal intracranial EEG, by comparing patient data to a normative map, has shown promise for the localisation of epileptogenic tissue an…
Effects of anterior temporal lobe resection on cortical morphology
Karoline Leiberg, Jane de Tisi, John S Duncan +6
Anterior temporal lobe resection (ATLR) is a surgical procedure to treat drug-resistant temporal lobe epilepsy (TLE). Resection may involve large amounts of cortical tissue. Here,…
Neuro-evolutionary evidence for a universal fractal primate brain shape
Yujiang Wang, Karoline Leiberg, Nathan Kindred +5
The cerebral cortex displays a bewildering diversity of shapes and sizes across and within species. Despite this diversity, we present a universal multi-scale description of primat…
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy
Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte +8
Neocortical epilepsy surgery fails to achieve post-operative seizure freedom in 30-40% of cases. It is not fully understood why surgery in some patients is unsuccessful. Comparing…
A library of quantitative markers of seizure severity
Sarah J. Gascoigne, Leonard Waldmann, Mariella Panagiotopoulou +16
Purpose: Understanding fluctuations of seizure severity within individuals is important for defining treatment outcomes and response to therapy, as well as developing novel treatme…
Intracranial EEG structure-function coupling predicts surgical outcomes in focal epilepsy
Nishant Sinha, John S. Duncan, Beate Diehl +9
Alterations to structural and functional brain networks have been reported across many neurological conditions. However, the relationship between structure and function -- their co…
Volumetric and structural connectivity abnormalities co-localise in TLE
Jonathan J. Horsley, Gabrielle M. Schroeder, Rhys H. Thomas +6
Patients with temporal lobe epilepsy (TLE) exhibit both volumetric and structural connectivity abnormalities relative to healthy controls. How these abnormalities inter-relate and…
Chronic iEEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states
Gabrielle M. Schroeder, Philippa J. Karoly, Matias Maturana +4
Background and Objectives: Many biological processes are modulated by rhythms on circadian and multidien timescales. In focal epilepsy, various seizure features, such as spread and…
Seizure pathways and seizure durations can vary independently within individual patients with focal epilepsy
Gabrielle M. Schroeder, Fahmida A. Chowdhury, Mark J. Cook +5
A seizure's electrographic dynamics are characterised by its spatiotemporal evolution, also termed dynamical "pathway" and the time it takes to complete that pathway, which results…
Long-term changes in functional connectivity predict responses to intracranial stimulation of the human brain
Christoforos Papasavvas, Peter Neal Taylor, Yujiang Wang
Targeted electrical stimulation of the brain perturbs neural networks and modulates their rhythmic activity both at the site of stimulation and at remote brain regions. Understandi…
Normative brain mapping of interictal intracranial EEG to localise epileptogenic tissue
Peter N Taylor, Christoforos A Papasavvas, Thomas W Owen +11
The identification of abnormal electrographic activity is important in a wide range of neurological disorders, including epilepsy for localising epileptogenic tissue. However, this…
Local Morphological Measures Confirm that Folding within Small Partitions of the Human Cortex Follows Universal Scaling Law
Karoline Leiberg, Christoforos Papasavvas, Yujiang Wang
The universal scaling law of cortical morphology describes cortical folding as the covariance of average grey matter thickness, pial surface area, and exposed surface area. It appl…