155 citations · 273 across the 14 of their papers we have counts for
11 papers · 1 filter
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy
Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte +8
Neocortical epilepsy surgery fails to achieve post-operative seizure freedom in 30-40% of cases. It is not fully understood why surgery in some patients is unsuccessful. Comparing…
A library of quantitative markers of seizure severity
Sarah J. Gascoigne, Leonard Waldmann, Mariella Panagiotopoulou +16
Purpose: Understanding fluctuations of seizure severity within individuals is important for defining treatment outcomes and response to therapy, as well as developing novel treatme…
Intracranial EEG structure-function coupling predicts surgical outcomes in focal epilepsy
Nishant Sinha, John S. Duncan, Beate Diehl +9
Alterations to structural and functional brain networks have been reported across many neurological conditions. However, the relationship between structure and function -- their co…
Volumetric and structural connectivity abnormalities co-localise in TLE
Jonathan J. Horsley, Gabrielle M. Schroeder, Rhys H. Thomas +6
Patients with temporal lobe epilepsy (TLE) exhibit both volumetric and structural connectivity abnormalities relative to healthy controls. How these abnormalities inter-relate and…
Seizure pathways and seizure durations can vary independently within individual patients with focal epilepsy
Gabrielle M. Schroeder, Fahmida A. Chowdhury, Mark J. Cook +5
A seizure's electrographic dynamics are characterised by its spatiotemporal evolution, also termed dynamical "pathway" and the time it takes to complete that pathway, which results…
Normative brain mapping of interictal intracranial EEG to localise epileptogenic tissue
Peter N Taylor, Christoforos A Papasavvas, Thomas W Owen +11
The identification of abnormal electrographic activity is important in a wide range of neurological disorders, including epilepsy for localising epileptogenic tissue. However, this…
Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy
Nishant Sinha, Natalie Peternell, Gabrielle M. Schroeder +6
Objective: To identify if whole-brain structural network alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic-clonic seizures (FBTCS) differ from…
Multivariate white matter alterations are associated with epilepsy duration
Tom W. Owen, Jane de Tisi, Sjoerd B. Vos +4
Previous studies investigating associations between white matter alterations and duration of temporal lobe epilepsy (TLE) have shown differing results, and were typically limited t…
Independent components of human brain morphology
Yujiang Wang, Tobias Ludwig, Bethany Little +7
Quantification of brain morphology has become an important cornerstone in understanding brain structure. Measures of cortical morphology such as thickness and surface area are freq…
Interictal intracranial EEG for predicting surgical success: the importance of space and time
Yujiang Wang, Nishant Sinha, Gabrielle M. Schroeder +8
Predicting post-operative seizure freedom using functional correlation networks derived from interictal intracranial EEG has shown some success. However, there are important challe…
The impact of epilepsy surgery on the structural connectome and its relation to outcome
Peter N Taylor, Nishant Sinha, Yujiang Wang +6
Temporal lobe surgical resection brings seizure remission in up to 80% of patients, with long-term complete seizure freedom in 41%. However, it is unclear how surgery impacts on th…