most citedA versatile trend test for the evaluation of tumor incidences in long-term carcinogenicity bioassays

2 citations · 4 across the 6 of their papers we have counts for

collaborators

6 papers

stat.ME2026

Prediction intervals for overdispersed multinomial data with application to historical controls

Sören Budig, Frank Schaarschmidt, Max Menssen

In pharmaceutical and toxicological research, historical control data are increasingly used to validate concurrent control groups, typically via the construction of historical cont…

stat.ME2026

Including historical control data in simultaneous inference for pre-clinical multi-arm studies

Max Menssen, Carsten Kneuer, Gyamfi Akyianu +3

In pre- and non-clinical toxicology, the reduction of animal use is highly desireable. Although approaches for possible sample size reduction in the concurrent control group were s…

stat.AP2020★ 2 cited

A versatile trend test for the evaluation of tumor incidences in long-term carcinogenicity bioassays

Ludwig A. Hothorn, Atiar M. Rahman, Frank Schaarschmidt

For the evaluation of carcinogenicity bioassays a new trend test is proposed which is based on a maximum of arithmetic, ordinal, and logarithmic regression scores as well as the Wi…

stat.AP2020★ 1 cited

Model-based simultaneous inference for multiple subgroups and multiple endpoints

Charlotte Vogel, Frank Schaarschmidt, Christian Ritz +2

Various methodological options exist on evaluating differences in both subgroups and the overall population. Most desirable is the simultaneous study of multiple endpoints in sever…

stat.ME2020

A Tukey type trend test for repeated carcinogenicity bioassays, motivated by multiple glyphosate studies

Ludwig A. Hothorn, Frank Schaarschmidt

In the last two decades, significant methodological progress to the simultaneous inference of simple and complex randomized designs, particularly proportions as endpoints, occurred…

stat.ME2020★ 1 cited

A modified Armitage test for more than a linear trend on proportions

Ludwig A. Hothorn, Frank Schaarschmidt

The Armitage test for linear trend in proportions can be modified using the multiple marginal model approach for three regression models with arithmetic, ordinal and logarithmic do…