690 citations · 717 across the 10 of their papers we have counts for
10 papers
Signal Recovery Using a Spiked Mixture Model
Paul-Louis Delacour, Sander Wahls, Jeffrey M. Spraggins +2
We introduce the spiked mixture model (SMM) to address the problem of estimating a set of signals from many randomly scaled and noisy observations. Subsequently, we design a novel…
Virtual Staining of Label-Free Tissue in Imaging Mass Spectrometry
Yijie Zhang, Luzhe Huang, Nir Pillar +5
Imaging mass spectrometry (IMS) is a powerful tool for untargeted, highly multiplexed molecular mapping of tissue in biomedical research. IMS offers a means of mapping the spatial…
Harmonizing the Generation and Pre-publication Stewardship of FAIR Image Data
Nikki Bialy, Frank Alber, Brenda Andrews +44
Alongside molecular insights into genes and proteins, biological imaging holds great promise for deepening scientific understanding of complex cellular systems and advancing predic…
Super-resolution multi-contrast unbiased eye atlases with deep probabilistic refinement
Ho Hin Lee, Adam M. Saunders, Michael E. Kim +15
Purpose: Eye morphology varies significantly across the population, especially for the orbit and optic nerve. These variations limit the feasibility and robustness of generalizing…
Multi-Contrast Computed Tomography Atlas of Healthy Pancreas
Yinchi Zhou, Ho Hin Lee, Yucheng Tang +6
With the substantial diversity in population demographics, such as differences in age and body composition, the volumetric morphology of pancreas varies greatly, resulting in disti…
New views of old proteins: clarifying the enigmatic proteome
Participants in a NIH Workshop on Functional, Integrative Proteomics, : +20
All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition…
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging
John W. Hickey, Elizabeth K. Neumann, Andrea J. Radtke +21
Tissues and organs are composed of distinct cell types that must operate in concert to perform physiological functions. Efforts to create high-dimensional biomarker catalogs of the…
Multi-Contrast Computed Tomography Healthy Kidney Atlas
Ho Hin Lee, Yucheng Tang, Kaiwen Xu +8
The construction of three-dimensional multi-modal tissue maps provides an opportunity to spur interdisciplinary innovations across temporal and spatial scales through information i…
Construction and Usage of a Human Body Common Coordinate Framework Comprising Clinical, Semantic, and Spatial Ontologies
Katy Börner, Ellen M. Quardokus, Bruce W. Herr +14
The National Institutes of Health's (NIH) Human Biomolecular Atlas Program (HuBMAP) aims to create a comprehensive high-resolution atlas of all the cells in the healthy human body.…
Mapping the Human Body at Cellular Resolution -- The NIH Common Fund Human BioMolecular Atlas Program
Michael P Snyder, Shin Lin, Amanda Posgai +22
Transformative technologies are enabling the construction of three dimensional (3D) maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years,…