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stat.ME2025
Evaluating the impact of outcome delay on the efficiency of two-arm group-sequential trials
Aritra Mukherjee, Michael J. Grayling, James M. S. Wason
Adaptive designs(AD) are a broad class of trial designs that allow preplanned modifications based on patient data providing improved efficiency and flexibility. However, a delay in…
stat.ME2024
Cross-validated risk scores adaptive enrichment (CADEN) design
Svetlana Cherlin, James M S Wason
We propose a Cross-validated ADaptive ENrichment design (CADEN) in which a trial population is enriched with a subpopulation of patients who are predicted to benefit from the treat…
stat.ME2024
Developing a predictive signature for two trial endpoints using the cross-validated risk scores method
Svetlana Cherlin, James M. S. Wason
The existing cross-validated risk scores (CVRS) design has been proposed for developing and testing the efficacy of a treatment in a high-efficacy patient group (the sensitive grou…