3 papers
stat.ME2025
Evaluating the impact of outcome delay on the efficiency of two-arm group-sequential trials
Aritra Mukherjee, Michael J. Grayling, James M. S. Wason
Adaptive designs(AD) are a broad class of trial designs that allow preplanned modifications based on patient data providing improved efficiency and flexibility. However, a delay in…
stat.ME2024
Optimal Bayesian stepped-wedge cluster randomised trial designs for binary outcome data
Laura Etfer, James M. S. Wason, Michael J. Grayling
Under a generalised estimating equation analysis approach, approximate design theory is used to determine Bayesian D-optimal designs. For two examples, considering simple exchangea…
stat.AP2024
Utilising high-dimensional data in randomised clinical trials: a review of methods and practice
Svetlana Cherlin, Theophile Bigirumurame, Michael J Grayling +6
Introduction: Even in effectively conducted randomised trials, the probability of a successful study remains relatively low. With recent advances in the next-generation sequencing…