87 citations · 372 across the 31 of their papers we have counts for
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Modelling transcriptional silencing and its coupling to 3D genome organisation
Massimiliano Semeraro, Giuseppe Negro, Davide Marenduzzo +1
Timely up- or down-regulation of gene expression is crucial for cellular differentiation and function. While gene upregulation via transcriptional activators has been extensively i…
A unified-field theory of genome organization and gene regulation
Giuseppe Negro, Massimiliano Semeraro, Perter R Cook +1
Our aim is to predict how often genic and non-genic promoters fire within a cell. We first review a parsimonious pan-genomic model for genome organization and gene regulation, wher…
Cluster size determines internal structure of transcription factories in human cells
Massimiliano Semeraro, Giuseppe Negro, Giada Forte +4
Transcription is a fundamental cellular process, and the first step of gene expression. In human cells, it depends on the binding to chromatin of various proteins, including RNA po…