12 citations · 84 across the 25 of their papers we have counts for
8 papers · 1 filter
Persistent Laplacian projected Omicron BA.4 and BA.5 to become new dominating variants
Jiahui Chen, Yuchi Qiu, Rui Wang +1
Due to its high transmissibility, Omicron BA.1 ousted the Delta variant to become a dominating variant in late 2021 and was replaced by more transmissible Omicron BA.2 in March 202…
Emerging vaccine-breakthrough SARS-CoV-2 variants
Rui Wang, Jiahui Chen, Yuta Hozumi +2
The recent global surge in COVID-19 infections has been fueled by new SARS-CoV-2 variants, namely Alpha, Beta, Gamma, Delta, etc. The molecular mechanism underlying such surge is e…
Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2
Kaifu Gao, Rui Wang, Jiahui Chen +6
The deadly coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gone out of control globally. Despite much effort…
Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies
Jiahui Chen, Kaifu Gao, Rui Wang +1
Antibody therapeutics and vaccines are among our last resort to end the raging COVID-19 pandemic. They, however, are prone to over 5,000 mutations on the spike (S) protein uncovere…
Review of COVID-19 Antibody Therapies
Jiahui Chen, Kaifu Gao, Rui Wang +2
Under the global health emergency caused by coronavirus disease 2019 (COVID-19), efficient and specific therapies are urgently needed. Compared with traditional small-molecular dru…
Mutations strengthened SARS-CoV-2 infectivity
Jiahui Chen, Rui Wang, Menglun Wang +1
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is a major concern in coronavirus disease 2019 (COVID-19) prevention and economic reopening. However, rigor…
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 92 crystal structures
Duc D Nguyen, Kaifu Gao, Jiahui Chen +2
Currently, there is no effective antiviral drugs nor vaccine for coronavirus disease 2019 (COVID-19) caused by acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to its hig…
Repositioning of 8565 existing drugs for COVID-19
Kaifu Gao, Duc Duy Nguyen, Jiahui Chen +2
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected near 5 million people and led to over 0.3 milli…