3 papers
q-bio.PE2020
Survival of the densest accounts for the expansion of mitochondrial mutations in ageing
Ferdinando Insalata, Hanne Hoitzing, Juvid Aryaman +1
The expansion of deleted mitochondrial DNA (mtDNA) molecules has been linked to ageing, particularly in skeletal muscle fibres; its mechanism has remained unclear for three decades…
q-bio.SC2018
Mitochondrial network state scales mtDNA genetic dynamics
Juvid Aryaman, Charlotte Bowles, Nick S. Jones +1
Mitochondrial DNA (mtDNA) mutations cause severe congenital diseases but may also be associated with healthy aging. MtDNA is stochastically replicated and degraded, and exists with…
q-bio.SC2018
Mitochondrial heterogeneity
Juvid Aryaman, Iain G. Johnston, Nick S. Jones
Cell-to-cell heterogeneity drives a range of (patho)physiologically important phenomena, such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly…