68 citations · 76 across the 5 of their papers we have counts for
5 papers
A Comparison of Estimand and Estimation Strategies for Clinical Trials in Early Parkinson's Disease
Alessandro Noci, Marcel Wolbers, Markus Abt +4
Parkinson's disease (PD) is a chronic, degenerative neurological disorder. PD cannot be prevented, slowed or cured as of today but highly effective symptomatic treatments are avail…
Standard and reference-based conditional mean imputation
Marcel Wolbers, Alessandro Noci, Paul Delmar +3
Clinical trials with longitudinal outcomes typically include missing data due to missed assessments or structural missingness of outcomes after intercurrent events handled with a h…
A pragmatic adaptive enrichment design for selecting the right target population for cancer immunotherapies
Anh Nguyen Duc, Dominik Heinzmann, Claude Berge +1
One of the challenges in the design of confirmatory trials is to deal with uncertainties regarding the optimal target population for a novel drug. Adaptive enrichment designs (AED)…
Principal Stratum Strategy: Potential Role in Drug Development
Björn Bornkamp, Kaspar Rufibach, Jianchang Lin +6
A randomized trial allows estimation of the causal effect of an intervention compared to a control in the overall population and in subpopulations defined by baseline characteristi…
Statistical Issues and Recommendations for Clinical Trials Conducted During the COVID-19 Pandemic
R. Daniel Meyer, Bohdana Ratitch, Marcel Wolbers +15
The COVID-19 pandemic has had and continues to have major impacts on planned and ongoing clinical trials. Its effects on trial data create multiple potential statistical issues. Th…