6 papers
Dynamic Guided and Domain Applicable Safeguards for Enhanced Security in Large Language Models
Weidi Luo, He Cao, Zijing Liu +5
With the extensive deployment of Large Language Models (LLMs), ensuring their safety has become increasingly critical. However, existing defense methods often struggle with two key…
ControlMol: Adding Substructure Control To Molecule Diffusion Models
Qi Zhengyang, Liu Zijing, Zhang Jiying +2
Due to the vast design space of molecules, generating molecules conditioned on a specific sub-structure relevant to a particular function or therapeutic target is a crucial task in…
InstructMol: Multi-Modal Integration for Building a Versatile and Reliable Molecular Assistant in Drug Discovery
He Cao, Zijing Liu, Xingyu Lu +2
The rapid evolution of artificial intelligence in drug discovery encounters challenges with generalization and extensive training, yet Large Language Models (LLMs) offer promise in…
Efficient Antibody Structure Refinement Using Energy-Guided SE(3) Flow Matching
Jiying Zhang, Zijing Liu, Shengyuan Bai +3
Antibodies are proteins produced by the immune system that recognize and bind to specific antigens, and their 3D structures are crucial for understanding their binding mechanism an…
SMILES-Prompting: A Novel Approach to LLM Jailbreak Attacks in Chemical Synthesis
Aidan Wong, He Cao, Zijing Liu +1
The increasing integration of large language models (LLMs) across various fields has heightened concerns about their potential to propagate dangerous information. This paper specif…
CAPE: A Chinese Dataset for Appraisal-based Emotional Generation using Large Language Models
June M. Liu, He Cao, Renliang Sun +3
Generating emotionally appropriate responses in conversations with large language models presents a significant challenge due to the complexities of human emotions and cognitive pr…