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math.PR2024
Analysis of singularly perturbed stochastic chemical reaction networks motivated by applications to epigenetic cell memory
Simone Bruno, Felipe A. Campos, Yi Fu +2
Epigenetic cell memory, the inheritance of gene expression patterns across subsequent cell divisions, is a critical property of multi-cellular organisms. In recent work [10], a sub…
q-bio.MN2024
Competition for binding targets results in paradoxical effects for simultaneous activator and repressor action -- Extended Version
M. Ali Al-Radhawi, Krishna Manoj, Dhruv D. Jatkar +3
In the context of epigenetic transformations in cancer metastasis, a puzzling effect was recently discovered, in which the elimination (knock-out) of an activating regulatory eleme…