2 citations · 2 across the 3 of their papers we have counts for
6 papers · 1 filter
Blinded sample size review for McNemar's test based on primary and surrogate endpoints
Markus Schepers, Werner Brannath, Esther Hoffmann +2
We develop blinded sample size re-estimation strategies for McNemar's test based on paired binary primary and secondary short-term surrogate endpoints. The development is motivated…
An exhaustive ADDIS principle for online FWER control
Lasse Fischer, Marta Bofill Roig, Werner Brannath
In this paper we consider online multiple testing with familywise error rate (FWER) control, where the probability of committing at least one type I error shall remain under contro…
The effect of estimating prevalences on the population-wise error rate
Remi Luschei, Werner Brannath
The population-wise error rate (PWER) is a type I error rate for clinical trials with multiple target populations. In such trials, a treatment is tested for its efficacy in each po…
A liberal type I error rate for studies in precision medicine
Werner Brannath, Charlie Hillner, Kornelius Rohmeyer
We introduce a new multiple type I error criterion for clinical trials with multiple populations. Such trials are of interest in precision medicine where the goal is to develop tre…
Point and interval estimation of the target dose using weighted regression modelling
Saswati Saha, Werner Brannath
In a Phase II dose-finding study with a placebo control, a new drug with several dose levels is compared with a placebo to test for the effectiveness of the new drug. The main focu…
A multiple testing framework for diagnostic accuracy studies with co-primary endpoints
Max Westphal, Antonia Zapf, Werner Brannath
Major advances have been made regarding the utilization of artificial intelligence in health care. In particular, deep learning approaches have been successfully applied for automa…