3 citations · 4 across the 9 of their papers we have counts for
7 papers · 1 filter
A Better Comparison under right-censoring: ABC Statistic for Equivalence Testing and Quantification
Simon Mack, Kathrin Möllenhoff, Dennis Dobler
The ABC (area between curves) statistic is an -distance which targets an easy-to-interpret estimand. Defined as the (normalized) integrated absolute distance between two survi…
Estimating effect thresholds and beyond: A flexible framework for multivariate alert detection
Lucia Ameis, Niklas Hagemann, Kathrin Möllenhoff
Evaluating the influence of continuous covariates, like exposure time or dose, on a response variable is a pivotal objective in the assessment of a compound's effect, particularly…
Capturing heterogeneous time-variation in covariate effects in non-proportional hazard regression models
Niklas Hagemann, Thomas Kneib, Kathrin Möllenhoff
A central focus in survival analysis is examining how covariates influence survival time. These covariate effects are often found to be either time-varying, heterogeneous - such as…
Identification of changes in gene expression
Lucia Ameis, Kathrin Möllenhoff
Evaluating the change in gene expression is a common goal in many research areas, such as in toxicological studies as well as in clinical trials. In practice, the analysis is often…
Survival analysis under non-proportional hazards: investigating non-inferiority or equivalence in time-to-event data
Kathrin Möllenhoff, Achim Tresch
The classical approach to analyze time-to-event data, e.g. in clinical trials, is to fit Kaplan-Meier curves yielding the treatment effect as the hazard ratio between treatment gro…
Equivalence tests for binary efficacy-toxicity responses
Holger Dette, Kathrin Möllenhoff, Frank Bretz
Clinical trials often aim to compare a new drug with a reference treatment in terms of efficacy and/or toxicity depending on covariates such as, for example, the dose level of the…
Equivalence of dose response curves
Holger Dette, Kathrin Möllenhoff, Stanislav Volgushev +1
This paper investigates the problem whether the difference between two parametric models describing the relation between a response variable and several covariates in two…