12 citations · 12 across the 6 of their papers we have counts for
10 papers
Biomolecular crystallization in microfluidic devices
Nadine Candoni, Romain Grossier, Stéphane Veesler
This chapter presents an overview of microfluidic devices reported in the literature, used to develop methodologies for nucleation of biomolecules, with crystal size control, and f…
Rapid Polymorphic Screening using Sessile Microdroplets: Competitive Nucleation of Mannitol Polymorphs
Ruel Cedeno, Romain Grossier, Nadine Candoni +1
We developed a rapid polymorphic screening approach based on contracting sessile microdroplets which offers several advantages: (1) achieves very high supersaturation to facilitate…
Microdroplet Approach for Measuring Aqueous Solubility and Nucleation Kinetics of a Metastable Polymorph: The case of KDP Phase IV
Ruel Cedeno, Romain Grossier, Nadine Candoni +1
Solubility and interfacial energy are two fundamental parameters underlying the competitive nucleation of polymorphs. However, solubility measurement of metastable phases comes wit…
CNT effective interfacial energy and pre-exponential kinetic factor from measured NaCl crystal nucleation time distributions in contracting microdroplets
Ruel Cedeno, Romain Grossier, Nadine Candoni +3
Nucleation, the birth of a stable cluster from disorder, is inherently stochastic. Yet up to date, there are no quantitative studies on NaCl nucleation that accounts for its stocha…
Modular microfluidic platform for solubility measurement, nucleation statistics and polymorph screening of active pharmaceutical ingredients: Irbesartan, Rimonabant, Aripiprazole and Sulfathiazole
Mathilde Lambert, Romain Grossier, Mehdi Lagaize +5
Drug efficacy strongly relies on the solid state of the active pharmaceutical ingredient. Classical solid-state screening methods involve different solvent compositions and supersa…
Evaporation Dynamics of Sessile Saline Microdroplets in Oil
Ruel Cedeno, Romain Grossier, Nadine Candoni +2
The occurrence of concentration and temperature gradients in saline microdroplets evaporating directly in air makes them unsuitable for nucleation studies where homogeneous composi…
Nucleation in Sessile Saline Microdroplets: Induction Time Measurement via Deliquescence-Recrystallization Cycling
Ruel Cedeno, Romain Grossier, Mehdi Lagaize +4
Induction time, a measure of how long one will wait for nucleation to occur, is an important parameter in quantifying nucleation kinetics and its underlying mechanisms. Due to the…
Preparation of alginate hydrogel microparticles using droplet-based microfluidics: a review of methods
Cheng Zhang, Romain Grossier, Nadine Candoni +1
This review focuses on a microparticle-producing technique widely used for its efficacy in controlling physicochemical properties: droplet-based microfluidics. The review describes…
Microfluidics platform for polymorph screening directly from powder
Guillem Peybernès, Romain Grossier, Frédéric Villard +3
We describe a microfluidic platform for solid phase screening using extremely small quantities of raw materials. Based on our previous setup for solubility measurement that generat…
Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction
Charline Gerard, Gilles Ferry, Laurent Vuillard +7
We used a microfluidic platform to address the problems of obtaining diffraction quality crystals and crystal handling during transfer to the X-ray diffractometer. We optimize crys…