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q-bio.BM2022
The low-entropy hydration shell at the binding site of spike RBD determines the contagiousness of SARS-CoV-2 variants
Lin Yang, Shuai Guo, Chengyu Houc +9
The infectivity of SARS-CoV-2 depends on the binding affinity of the receptor-binding domain (RBD) of the spike protein with the angiotensin converting enzyme 2 (ACE2) receptor. Th…
q-bio.BM2022
Space Layout of Low-entropy Hydration Shells Guides Protein Binding
Lin Yang, Shuai Guo, Chengyu Hou +9
Protein-protein binding enables orderly and lawful biological self-organization, and is therefore considered a miracle of nature. Protein-protein binding is steered by electrostati…