645 citations · 1.1k across the 27 of their papers we have counts for
15 papers · 1 filter
Evidence-based diagnostic reasoning with multi-agent copilot for human pathology
Luca L. Weishaupt, Chengkuan Chen, Drew F. K. Williamson +8
Pathology is experiencing rapid digital transformation driven by whole-slide imaging and artificial intelligence (AI). While deep learning-based computational pathology has achieve…
AI-driven 3D Spatial Transcriptomics
Cristina Almagro-Pérez, Andrew H. Song, Luca Weishaupt +13
A comprehensive three-dimensional (3D) map of tissue architecture and gene expression is crucial for illuminating the complexity and heterogeneity of tissues across diverse biomedi…
HEST-1k: A Dataset for Spatial Transcriptomics and Histology Image Analysis
Guillaume Jaume, Paul Doucet, Andrew H. Song +8
Spatial transcriptomics enables interrogating the molecular composition of tissue with ever-increasing resolution and sensitivity. However, costs, rapidly evolving technology, and…
Morphological Prototyping for Unsupervised Slide Representation Learning in Computational Pathology
Andrew H. Song, Richard J. Chen, Tong Ding +3
Representation learning of pathology whole-slide images (WSIs) has been has primarily relied on weak supervision with Multiple Instance Learning (MIL). However, the slide represent…
Transcriptomics-guided Slide Representation Learning in Computational Pathology
Guillaume Jaume, Lukas Oldenburg, Anurag Vaidya +5
Self-supervised learning (SSL) has been successful in building patch embeddings of small histology images (e.g., 224x224 pixels), but scaling these models to learn slide embeddings…
A Foundational Multimodal Vision Language AI Assistant for Human Pathology
Ming Y. Lu, Bowen Chen, Drew F. K. Williamson +8
The field of computational pathology has witnessed remarkable progress in the development of both task-specific predictive models and task-agnostic self-supervised vision encoders.…
A General-Purpose Self-Supervised Model for Computational Pathology
Richard J. Chen, Tong Ding, Ming Y. Lu +17
Tissue phenotyping is a fundamental computational pathology (CPath) task in learning objective characterizations of histopathologic biomarkers in anatomic pathology. However, whole…
Towards a Visual-Language Foundation Model for Computational Pathology
Ming Y. Lu, Bowen Chen, Drew F. K. Williamson +10
The accelerated adoption of digital pathology and advances in deep learning have enabled the development of powerful models for various pathology tasks across a diverse array of di…
Visual Language Pretrained Multiple Instance Zero-Shot Transfer for Histopathology Images
Ming Y. Lu, Bowen Chen, Andrew Zhang +6
Contrastive visual language pretraining has emerged as a powerful method for either training new language-aware image encoders or augmenting existing pretrained models with zero-sh…
Modeling Dense Multimodal Interactions Between Biological Pathways and Histology for Survival Prediction
Guillaume Jaume, Anurag Vaidya, Richard Chen +3
Integrating whole-slide images (WSIs) and bulk transcriptomics for predicting patient survival can improve our understanding of patient prognosis. However, this multimodal task is…
Differentiable Zooming for Multiple Instance Learning on Whole-Slide Images
Kevin Thandiackal, Boqi Chen, Pushpak Pati +4
Multiple Instance Learning (MIL) methods have become increasingly popular for classifying giga-pixel sized Whole-Slide Images (WSIs) in digital pathology. Most MIL methods operate…
Algorithm Fairness in AI for Medicine and Healthcare
Richard J. Chen, Tiffany Y. Chen, Jana Lipkova +5
In the current development and deployment of many artificial intelligence (AI) systems in healthcare, algorithm fairness is a challenging problem in delivering equitable care. Rece…
Pan-Cancer Integrative Histology-Genomic Analysis via Interpretable Multimodal Deep Learning
Richard J. Chen, Ming Y. Lu, Drew F. K. Williamson +8
The rapidly emerging field of deep learning-based computational pathology has demonstrated promise in developing objective prognostic models from histology whole slide images. Howe…
Fast and Scalable Image Search For Histology
Chengkuan Chen, Ming Y. Lu, Drew F. K. Williamson +3
The expanding adoption of digital pathology has enabled the curation of large repositories of histology whole slide images (WSIs), which contain a wealth of information. Similar pa…
Pathomic Fusion: An Integrated Framework for Fusing Histopathology and Genomic Features for Cancer Diagnosis and Prognosis
Richard J. Chen, Ming Y. Lu, Jingwen Wang +4
Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, mo…