6 citations · 12 across the 5 of their papers we have counts for
5 papers
Modelling the 3D spatiotemporal organisation of chromatin replication
G. Forte, S. Buonomo, P. R. Cook +3
We propose a polymer model for the dynamics of chromatin replication in three dimensional space. Our simulations indicate that both immobile and tracking replisomes may self-assemb…
A unified-field theory of genome organization and gene regulation
Giuseppe Negro, Massimiliano Semeraro, Perter R Cook +1
Our aim is to predict how often genic and non-genic promoters fire within a cell. We first review a parsimonious pan-genomic model for genome organization and gene regulation, wher…
Extrusion without a motor: a new take on the loop extrusion model of genome organization
C. A. Brackley, J. Johnson, D. Michieletto +4
Chromatin loop extrusion is a popular model for the formation of CTCF loops and topological domains. Recent HiC data have revealed a strong bias in favour of a particular arrangeme…
Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations
Peter R. Cook, Davide Marenduzzo
Current models for the folding of the human genome see a hierarchy stretching down from chromosome territories, through A/B compartments and TADs (topologically-associating domains…
Binding of bivalent transcription factors to active and inactive regions folds human chromosomes into loops, rosettes and domains
C. A. Brackley, J. Johnson, S. Kelly +2
Biophysicists are modeling conformations of interphase chromosomes, often basing the strengths of interactions between segments distant on the genetic map on contact frequencies de…