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8-oxoguanine 1dna damage 1misincorporation 1molecular dynamics 1polymerase lambda 1quantum chemistry 1

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physics.bio-ph2026

Conformational Dynamics of 8-Oxoguanine Mispairing Reveal a Mechanism of Polymerase λ Misincorporation

George Ferguson, Louie Slocombe, Max Winokan +2

The paper uses quantum mechanical and molecular dynamics simulations to study how the oxidative DNA lesion 8‑oxoguanine pairs with adenine inside polymerase λ, showing that a Hoogs…