2 papers
stat.ME2025
Balancing the effective sample size in prior across different doses in the curve-free Bayesian decision-theoretic design for dose-finding trials
Jiapeng Xu, Dehua Bi, Shenghua Kelly Fan +2
The primary goal of dose allocation in phase I trials is to minimize patient exposure to subtherapeutic or excessively toxic doses, while accurately recommending a phase II dose th…
stat.ME2025
On the two-step hybrid design for augmenting randomized trials using real-world data
Jiapeng Xu, Ruben P. A. van Eijk, Alicia Ellis +8
Hybrid clinical trials, that borrow real-world data (RWD), are gaining interest, especially for rare diseases. They assume RWD and randomized control arm be exchangeable, but viola…