Estimating the Complier Average Causal Effect in Randomised Controlled Trials with Non-Compliance: A Comparative Simulation Study of the Instrumental Variables and Per-Protocol Analyses

Theodosios Papazoglou, Ed Waddingham, Alastair Young

Objective: Randomised controlled trials (RCTs) are widely considered as gold standard for assessing the effectiveness of new health interventions. When treatment non-compliance is…