4 papers · 1 filter
Early Pregnancy Treatment Decisions: Designing Perinatal Pharmacoepidemiology Studies using Real-World Data
Mollie E. Wood, Robert W. Platt, Jennifer A. Hutcheon +5
Research on the use of medications during pregnancy has two primary goals: to detect signals that medications may be harmful to a pregnant individual or fetus, and to support bette…
Comparing causal estimands from sequential nested versus single point target trials: A simulation study
Catherine Wiener, Chase D. Latour, Kathleen Hurwitz +4
Sequential nested trial (SNT) emulation is a powerful approach for maximizing precision and avoiding time-related biases. However, there exists little discussion about the implied…
Bias in studies of prenatal exposures using real-world data due to pregnancy identification method
Chase D. Latour, Jessie K. Edwards, Michele Jonsson Funk +3
Background: Researchers typically identify pregnancies in healthcare data based on observed outcomes (e.g., delivery). This outcome-based approach misses pregnancies that received…
Healthy Live Births Should be Considered as Competing Events when Estimating the Total Effect of Prenatal Medication Use on Pregnancy Outcomes
Chase D. Latour, Mark Klose, Jessie K. Edwards +3
Pregnancy loss is recognized as an important competing event in studies of prenatal medication use. However, a healthy live birth also precludes subsequent adverse pregnancy outcom…