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DNA origami 1high-resolution mass measurement 1mass photometry 1megadalton assemblies 1nanofluidic scattering microscopy 1single-molecule measurement 1

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physics.optics2026

High-resolution single-molecule mass measurement of megadalton assemblies in solution

Tereza Roesel, Evangelos Efraimidis, Niklas Hansen +5

The authors introduce nanofluidic scattering microscopy, which continuously tracks single molecules in solution to repeatedly sample and temporally average their scattering signals…