223 citations · 652 across the 17 of their papers we have counts for
17 papers
Stochastic clonal dynamics and genetic turnover in exponentially growing populations
Arman Angaji, Christoph Velling, Johannes Berg
We consider an exponentially growing population of cells undergoing mutations and ask about the effect of reproductive fluctuations (genetic drift) on its long-term evolution. We c…
Pervasive adaptation of gene expression in Drosophila
Armita Nourmohammad, Joachim Rambeau, Torsten Held +2
Gene expression levels are important molecular quantitative traits that link genotypes to molecular functions and fitness. In Drosophila, population-genetic studies in recent years…
Multiple-line inference of selection on quantitative traits
Nico Riedel, Bhavin S. Khatri, Michael Lässig +1
Trait differences between species may be attributable to natural selection. However, quantifying the strength of evidence for selection acting on a particular trait is a difficult…
What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems
Prasanna M. Bhogale, Robin A. Sorg, Jan-Willem Veening +1
Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in proc…
Can we always sweep the details of RNA-processing under the carpet?
Filippos D. Klironomos, Juliette de Meaux, Johannes Berg
RNA molecules follow a succession of enzyme-mediated processing steps from transcription until maturation. The participating enzymes, for example the spliceosome for mRNAs and Dros…
A statistical mechanics approach to the sample deconvolution problem
Nico Riedel, Johannes Berg
In a multicellular organism different cell types express a gene in different amounts. Samples from which gene expression levels can be measured typically contain a mixture of diffe…