21 citations · 32 across the 9 of their papers we have counts for
9 papers
VCF2Networks: applying Genotype Networks to Single Nucleotide Variants data
Giovanni Marco Dall'Olio, Ali R. Vahdati, Bertranpetit Jaume +2
Summary: Genotype networks are a method used in systems biology to study the innovability of a given phenotype, determining whether the phenotype is robust to mutations, and how do…
Human Genome Variation and the concept of Genotype Networks
Giovanni Marco Dall'Olio, Jaume Bertranpetit, Andreas Wagner +1
Genotype networks are a method used in systems biology to study the "innovability" of a set of genotypes having the same phenotype. In the past they have been applied to determine…
Environmental versatility promotes modularity in genome-scale metabolic networks
Areejit Samal, Andreas Wagner, Olivier C. Martin
The ubiquity of modules in biological networks may result from an evolutionary benefit of a modular organization. For instance, modularity may increase the rate of adaptive evoluti…
Genotype networks, innovation, and robustness in sulfur metabolism
João F. Matias Rodrigues, Andreas Wagner
Metabolic networks are complex systems that comprise hundreds of chemical reactions which synthesize biomass molecules from chemicals in an organism's environment. The metabolic ne…
Genotype networks in metabolic reaction spaces
Areejit Samal, Joao F. Matias Rodrigues, Jürgen Jost +2
Background: A metabolic genotype comprises all chemical reactions an organism can catalyze via enzymes encoded in its genome. A genotype is viable in a given environment if it is c…
Quantifying Slow Evolutionary Dynamics in RNA Fitness Landscapes
P. Sulc, A. Wagner, O. C. Martin
We re-examine the evolutionary dynamics of RNA secondary structures under directional selection towards an optimum RNA structure. We find that the punctuated equilibria lead to a v…