2 papers
q-bio.QM2025
Evaluation of optimal cut-offs and dichotomous combinations for two biomarkers to improve patient selection
Gina DAngelo, Di Ran, Binbing Yu
Background Identifying the right cut-off for continuous biomarkers in clinical trials is important to identify subgroups of patients who are at greater risk of disease or more like…
stat.ME2025
Utility-Based Dose Optimization Approaches for Multiple-Dose Randomized Trial Designs Accounting for Multiple Endpoints
Gina DAngelo, Guannan Chen, Di Ran
The initiation of dose optimization has driven a paradigm shift in oncology clinical trials to determine the optimal biological dose (OBD). Early-phase trials with randomized doses…