2 papers
stat.ME2025
Conditional Inference for Secondary Outcomes Based on the Testing Result for the Primary Outcome in Clinical Trials
Tianyu Pan, Vivek Charu, Ying Lu +1
In clinical trials, inferences on clinical outcomes are often made conditional on specific selective processes. For instance, only when a treatment demonstrates a significant effec…
stat.ME2025
On the two-step hybrid design for augmenting randomized trials using real-world data
Jiapeng Xu, Ruben P. A. van Eijk, Alicia Ellis +8
Hybrid clinical trials, that borrow real-world data (RWD), are gaining interest, especially for rare diseases. They assume RWD and randomized control arm be exchangeable, but viola…