2 papers
q-bio.PE2025
Population dynamics of multiple ecDNA types
Elisa Scanu, Benjamin Werner, Weini Huang
Extrachromosomal DNA (ecDNA) can drive oncogene amplification, gene expression and intratumor heterogeneity, representing a major force in cancer initiation and progression. The ph…
q-bio.PE2024
Single-cell mutational burden distributions in birth-death processes
Christo Morison, Dudley Stark, Weini Huang
Genetic mutations are footprints of tumour growth. While mutation data in bulk samples has been used to infer evolutionary parameters hard to measure in vivo, the advent of single-…