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5 papers

quant-ph2026

SQD-Enabled Circuit Compression for Resource-Efficient Quantum Chemistry

Kangyu Zheng, Yidong Zhou, Jinglei Cheng +3

The paper introduces two methods—gradient-based operator pruning and Clifford rounding—to compress VQE circuits used with Subspace Quantum Diagonalization, achieving large reductio…

physics.chem-ph2026

Q-Score: A Quantum-Native Scoring Function for Molecular Docking

Kangyu Zheng, Yidong Zhou, Ruihao Li +3

Molecular docking predicts how a small molecule binds to a protein and is a key bottleneck in drug discovery. Classical scoring functions sum empirical pairwise contacts, blind to…

quant-ph2026

QCS-ADME: Quantum Circuit Search for Drug Property Prediction with Imbalanced Data and Regression Adaptation

Kangyu Zheng, Tianfan Fu, Zhiding Liang

The biomedical field is beginning to explore the use of quantum machine learning (QML) for tasks traditionally handled by classical machine learning, especially in predicting ADME…

cs.LG2026

Beyond Affinity: A Benchmark of 1D, 2D, and 3D Methods Reveals Critical Trade-offs in Structure-Based Drug Design

Kangyu Zheng, Kai Zhang, Jiale Tan +7

Currently, the field of structure-based drug design is dominated by three main types of algorithms: search-based algorithms, deep generative models, and reinforcement learning. Whi…

cs.CV2025

Argus: Benchmarking and Enhancing Vision-Language Models for 3D Radiology Report Generation

Che Liu, Zhongwei Wan, Yuqi Wang +5

Automatic radiology report generation holds significant potential to streamline the labor-intensive process of report writing by radiologists, particularly for 3D radiographs such…