15 citations · 82 across the 21 of their papers we have counts for
4 papers · 1 filter
Toward understanding of the role of reversibility of phenotypic switching in the evolution of resistance to therapy
Denis Horvath, Branislav Brutovsky
Reversibility of state transitions is intensively studied topic in many scientific disciplines over many years. In cell biology, it plays an important role in epigenetic variation…
Structure of Intratumor Heterogeneity: Is Cancer Hedging Its Bets?
B. Brutovsky, D. Horvath
Development of resistance limits transferability of most anticancer therapies into curative treatment and understanding mechanisms beyond it remains a big challenge. Many high reso…
Optimization Aspects of Carcinogenesis
B. Brutovsky, D. Horvath
Any process in which competing solutions replicate with errors and numbers of their copies depend on their respective fitnesses is the evolutionary optimization process. As during…
The efficiency of individual optimization in the conditions of competitive growth
J. Kocisova, D. Horvath, B. Brutovsky
The paper aims to discuss statistical properties of the multi-agent based model of competitive growth. Each of the agents is described by growth (or decay) rule of its virtual "mas…