2 papers
stat.ME2025
CUI-MET: Clinical Utility Index Dose Optimization Approach for Multiple-Dose, Multiple-Outcome Randomized Trial Designs
Fanni Zhang, Kristine Broglio, Michael Sweeting +1
Dose optimization in oncology clinical trials has shifted from seeking the maximum tolerated dose to identifying the Optimal Biological Dose (OBD) that balances therapeutic benefit…
stat.ME2025
Predictive biomarker graphical approach (PRIME) for Precision medicine
Gina D'Angelo, Xiaowen Tian, Chuyu Deng +1
Precision medicine is an evolving area in the medical field and rely on biomarkers to make patient enrichment decisions, thereby providing drug development direction. A traditional…