580 citations · 859 across the 8 of their papers we have counts for
8 papers
Bringing the Algorithms to the Data -- Secure Distributed Medical Analytics using the Personal Health Train (PHT-meDIC)
Marius de Arruda Botelho Herr, Michael Graf, Peter Placzek +11
The need for data privacy and security -- enforced through increasingly strict data protection regulations -- renders the use of healthcare data for machine learning difficult. In…
Towards Increased Reliability, Transparency and Accessibility in Crosslinking Mass Spectrometry
Alexander Leitner, Alexandre M. J. J. Bonvin, Christoph H. Borchers +33
Crosslinking mass spectrometry (Crosslinking MS) has substantially matured as a method over the last two decades through parallel development in multiple labs, demonstrating its ap…
Population-specific design of de-immunized protein biotherapeutics
Benjamin Schubert, Charlotta Schärfe, Pierre Dönnes +3
Immunogenicity is a major problem during the development of biotherapeutics since it can lead to rapid clearance of the drug and adverse reactions. The challenge for biotherapeutic…
Genetic variation in human drug-related genes
Charlotta P. I. Schärfe, Roman Tremmel, Matthias Schwab +2
Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classical pharmacokinetic genes is rather well unders…
Sequence co-evolution gives 3D contacts and structures of protein complexes
Thomas A. Hopf, Charlotta P. I. Schärfe, João P. G. L. M. Rodrigues +4
Protein-protein interactions are fundamental to many biological processes. Experimental screens have identified tens of thousands of interactions and structural biology has provide…
Interplay of pH and Binding of Multivalent Metal Ions: Charge Inversion and Reentrant Condensation in Protein Solutions
Felix Roosen-Runge, Benjamin S. Heck, Fajun Zhang +2
Tuning of protein surface charge is a fundamental mechanism in biological systems. Protein charge is regulated in a physiological context by pH and interaction with counterions. We…