1k citations · 5k across the 17 of their papers we have counts for
3 papers · 1 filter
Sensitivity analysis of a computational model of the IKK-NF-κB-IκBα-A20 signal transduction network
Jaewook Joo, Steve Plimpton, Shawn Martin +2
The NF-κB signaling network plays an important role in many different compartments of the immune system during immune activation. Using a computational model of the NF-κB signaling…
Novel statistical ensemble analysis for simulating extrinsic noise-driven response in NF-κB signaling network
Jaewook Joo, Steven J. Plimpton, Jean-Loup Faulon
Cellular responses in the single cells are known to be highly heterogeneous and individualistic due to the strong influence by extrinsic and intrinsic noise. Here, we are concerned…
Noise-induced oscillatory shuttling of NF-κB in a two compartment IKK-NF-κB-IκB-A20 signaling model
Jaewook Joo, Steven J. Plimpton, Jean-Loup Faulon
NF-κB is a pleiotropic protein whose nucleo-cytoplasmic trafficking is tightly regulated by multiple negative feedback loops embedded in the NF-κB signaling network and contributes…