3 papers
cs.CL2025
Semantic Similarity-Informed Bayesian Borrowing for Quantitative Signal Detection of Adverse Events
François Haguinet, Jeffery L Painter, Gregory E Powell +2
We present a Bayesian dynamic borrowing (BDB) approach to enhance the quantitative identification of adverse events (AEs) in spontaneous reporting systems (SRSs). The method embeds…
cs.CL2025
Ontology-based Semantic Similarity Measures for Clustering Medical Concepts in Drug Safety
Jeffery L Painter, François Haguinet, Gregory E Powell +1
Semantic similarity measures (SSMs) are widely used in biomedical research but remain underutilized in pharmacovigilance. This study evaluates six ontology-based SSMs for clusterin…
cs.CL2025
PVLens: Enhancing Pharmacovigilance Through Automated Label Extraction
Jeffery L Painter, Gregory E Powell, Andrew Bate
Reliable drug safety reference databases are essential for pharmacovigilance, yet existing resources like SIDER are outdated and static. We introduce PVLens, an automated system th…