3 citations · 3 across the 4 of their papers we have counts for
4 papers
How to design a MAMS-ROCI (aka DURATIONS) randomised trial: the REFINE-Lung case study
Matteo Quartagno, Ehsan Ghorani, Tim P Morris +2
Background. The DURATIONS design has been recently proposed as a practical alternative to a standard two-arm non-inferiority design when the goal is to optimise some continuous asp…
Handling an uncertain control group event risk in non-inferiority trials: non-inferiority frontiers and the power-stabilising transformation
Matteo Quartagno, A. Sarah Walker, Abdel G. Babiker +4
Background. Non-inferiority (NI) trials are increasingly used to evaluate new treatments expected to have secondary advantages over standard of care, but similar efficacy on the pr…
Adding new experimental arms to randomised clinical trials: impact on error rates
Babak Choodari-Oskooei, Daniel J Bratton, Melissa R Gannon +3
Background: Experimental treatments pass through various stages of development. If a treatment passes through early phase experiments, the investigators may want to assess it in a…
Re-thinking non-inferiority: a practical trial design for optimising treatment duration
Matteo Quartagno, A. Sarah Walker, James R. Carpenter +2
Background: trials to identify the minimal effective treatment duration are needed in different therapeutic areas, including bacterial infections, TB and Hepatitis--C. However, sta…