3 citations · 3 across the 5 of their papers we have counts for
5 papers
How to design a MAMS-ROCI (aka DURATIONS) randomised trial: the REFINE-Lung case study
Matteo Quartagno, Ehsan Ghorani, Tim P Morris +2
Background. The DURATIONS design has been recently proposed as a practical alternative to a standard two-arm non-inferiority design when the goal is to optimise some continuous asp…
Improving clinical trial interpretation with ACCEPT analyses
Michelle N. Clements, Ian R. White, Andrew J. Copas +7
Effective decision making from randomised controlled clinical trials relies on robust interpretation of the numerical results. However, the language we use to describe clinical tri…
The DURATIONS randomised trial design: estimation targets, analysis methods and operating characteristics
Matteo Quartagno, James R. Carpenter, A. Sarah Walker +2
Background. Designing trials to reduce treatment duration is important in several therapeutic areas, including TB and antibiotics. We recently proposed a new randomised trial desig…
Handling an uncertain control group event risk in non-inferiority trials: non-inferiority frontiers and the power-stabilising transformation
Matteo Quartagno, A. Sarah Walker, Abdel G. Babiker +4
Background. Non-inferiority (NI) trials are increasingly used to evaluate new treatments expected to have secondary advantages over standard of care, but similar efficacy on the pr…
Re-thinking non-inferiority: a practical trial design for optimising treatment duration
Matteo Quartagno, A. Sarah Walker, James R. Carpenter +2
Background: trials to identify the minimal effective treatment duration are needed in different therapeutic areas, including bacterial infections, TB and Hepatitis--C. However, sta…