34 citations · 38 across the 6 of their papers we have counts for
9 papers
A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells
L E Wadkin, S Orozco-Fuentes, I Neganova +3
Human pluripotent stem cells (hPSCs) have promising clinical applications in regenerative medicine, drug-discovery and personalised medicine due to their potential to differentiate…
An introduction to the mathematical modelling of iPSCs
Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova +3
The aim of this chapter is to convey the importance and usefulness of mathematical modelling as a tool to achieve a deeper understanding of stem cell biology. We introduce key math…
OCT4 expression in human embryonic stem cells: spatio-temporal dynamics and fate transitions
Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova +5
The improved in-vitro regulation of human embryonic stem cell (hESC) pluripotency and differentiation trajectories is required for their promising clinical applications. The tempor…
The recent advances in the mathematical modelling of human pluripotent stem cells
L E Wadkin, S Orozco-Fuentes, I Neganova +3
Human pluripotent stem cells hold great promise for developments in regenerative medicine and drug design. The mathematical modelling of stem cells and their properties is necessar…
Quantification of the morphological characteristics of hESC colonies
Sirio Orozco-Fuentes, Irina Neganova, Laura E. Wadkin +5
The maintenance of the pluripotent state in human embryonic stem cells (hESCs) is critical for further application in regenerative medicine, drug testing and studies of fundamental…
Seeding hESCs to achieve optimal colony clonality
Laura E Wadkin, Sirio Orozco-Fuentes, Irina Neganova +5
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) have promising clinical applications which often rely on clonally-homogeneous cell populations. To ach…
Correlated random walks of human embryonic stem cell in-vitro
L E Wadkin, S Orozco-Fuentes, I Neganova +5
We perform a detailed analysis of the migratory motion of human embryonic stem cells in two-dimensions, both when isolated and in close proximity to another cell, recorded with tim…
Early warning signals in plant disease outbreaks
S. Orozco-Fuentes, G. Griffiths, M. J. Holmes +4
Summary 1. Infectious disease outbreaks in plants threaten ecosystems, agricultural crops and food trade. Currently, several fungal diseases are affecting forests worldwide, posing…
Order, intermittency and pressure fluctuations in a system of proliferating rods
Sirio Orozco-Fuentes, Denis Boyer
Non-motile elongated bacteria confined in two-dimensional open micro-channels can exhibit collective motion and form dense monolayers with nematic order if the cells proliferate, i…