56 citations · 100 across the 13 of their papers we have counts for
14 papers
Interplay between Contractivity and Monotonicity for Reaction Networks
Alon Duvall, M. Ali Al-Radhawi, Dhruv D. Jatkar +1
We establish a new relationship between monotonicity and contractivity and use this connection to describe a new general class of weakly contractive reaction networks. The new clas…
Competition for binding targets results in paradoxical effects for simultaneous activator and repressor action -- Extended Version
M. Ali Al-Radhawi, Krishna Manoj, Dhruv D. Jatkar +3
In the context of epigenetic transformations in cancer metastasis, a puzzling effect was recently discovered, in which the elimination (knock-out) of an activating regulatory eleme…
On structural contraction of biological interaction networks
M. Ali Al-Radhawi, David Angeli, Eduardo Sontag
Biological networks are customarily described as structurally robust. This means that they often function extremely well under large forms of perturbations affecting both the conce…
Graphical characterizations of robust stability in biological interaction networks
M. Ali Al-Radhawi
Previous studies have inferred robust stability of reaction networks by utilizing linear programs or iterative algorithms. Such algorithms become tedious or computationally infeasi…
Epigenetic factor competition reshapes the EMT landscape
M. Ali Al-Radhawi, Shubham Tripathi, Yun Zhang +2
The emergence of and transitions between distinct phenotypes in isogenic cells can be attributed to the intricate interplay of epigenetic marks, external signals, and gene regulato…
Long-term regulation of prolonged epidemic outbreaks in large populations via adaptive control: a singular perturbation approach
M. Ali Al-Radhawi, Mahdiar Sadeghi, Eduardo D. Sontag
Initial hopes of quickly eradicating the COVID-19 pandemic proved futile, and the goal shifted to controlling the peak of the infection, so as to minimize the load on healthcare sy…
Mediating Ribosomal Competition by Splitting Pools
Jared Miller, M. Ali Al-Radhawi, Eduardo D. Sontag
Synthetic biology constructs often rely upon the introduction of "circuit" genes into host cells, in order to express novel proteins and thus endow the host with a desired behavior…
A robust Lyapunov criterion for non-oscillatory behaviors in biological interaction networks
David Angeli, M. Ali Al-Radhawi, Eduardo Sontag
We introduce the notion of non-oscillation, propose a constructive method for its robust verification, and study its application to biological interaction networks (also known as,…
Maximizing average throughput in oscillatory biological synthesis systems: an optimal control approach
M. Ali Al-Radhawi, Michael Margaliot, Eduardo Sontag
A dynamical system entrains to a periodic input if its state converges globally to an attractor with the same period. In particular, for a constant input the state converges to a u…
Analysis of a reduced model of epithelial-mesenchymal fate determination in cancer metastasis as a singularly-perturbed monotone system
M. Ali Al-Radhawi, Eduardo D. Sontag
Tumor metastasis is one of the main factors responsible for the high fatality rate of cancer. Metastasis can occur after malignant cells transition from the epithelial phenotype to…
No Switching Policy is Optimal for a Positive Linear System with a Bottleneck Entrance
Mahdiar Sadeghi, M. Ali Al-Radhawi, Michael Margaliot +1
We consider a nonlinear SISO system that is a cascade of a scalar "bottleneck entrance" and an arbitrary Hurwitz positive linear system. This system entrains i.e. in response to a…
Multi-modality in gene regulatory networks with slow promoter kinetics
M. Ali Al-Radhawi, Domitilla Del Vecchio, Eduardo D. Sontag
Phenotypical variability in the absence of genetic variation often reflects complex energetic landscapes associated with underlying gene regulatory networks (GRNs). In this view, d…
Robust Lyapunov Functions for Reaction Networks: An Uncertain System Framework
M. Ali Al-Radhawi, David Angeli
We present a framework to transform the problem of finding a Lyapunov function of a Chemical Reaction Network (CRN) in concentration coordinates with arbitrary monotone kinetics in…
New Approach to the Stability of Chemical Reaction Networks: Piecewise Linear in Rates Lyapunov Functions
M. Ali Al-Radhawi, David Angeli
Piecewise-Linear in Rates (PWLR) Lyapunov functions are introduced for a class of Chemical Reaction Networks (CRNs). In addition to their simple structure, these functions are robu…