69 citations · 210 across the 10 of their papers we have counts for
10 papers
Modelling the Lymphatic Metastatic Progression Pathways of OPSCC from Multi-Institutional Datasets
Roman Ludwig, Adrian Schubert, Dorothea Barbatei +11
The elective clinical target volume (CTV-N) in oropharyngeal squamous cell carcinoma (OPSCC) is currently based mostly on the prevalence of lymph node metastases in different lymph…
Mathematical optimization of treatment schedules
Bram L. Gorissen, Jan Unkelbach, Thomas R. Bortfeld
In the past decades mathematical optimization has found its way into radiation therapy and has made profound practice changing impact. Today, virtually all advanced treatment deliv…
Optimization of spatiotemporally fractionated radiotherapy treatments with bounds on the achievable benefit
Melissa R. Gaddy, Sercan Yıldız, Jan Unkelbach +1
Spatiotemporal fractionation schemes, that is, treatments delivering different dose distributions in different fractions, may lower treatment side effects without compromising tumo…
Radiotherapy planning for glioblastoma based on a tumor growth model: Improving target volume delineation
Jan Unkelbach, Bjoern H. Menze, Ender Konukoglu +4
Glioblastoma are known to infiltrate the brain parenchyma instead of forming a solid tumor mass with a defined boundary. Only the part of the tumor with high tumor cell density can…
A Mathematical Programming Approach to the Fractionation Problem in Chemoradiotherapy
Ehsan Salari, Jan Unkelbach, Thomas Bortfeld
In concurrent chemoradiotherapy, chemotherapeutic agents are administered during the course of radiotherapy to enhance the primary tumor control. However, that often comes at the e…
Optimization of Radiation Therapy Fractionation Schedules in the Presence of Tumor Repopulation
Thomas Bortfeld, Jagdish Ramakrishnan, John N. Tsitsiklis +1
We analyze the effect of tumor repopulation on optimal dose delivery in radiation therapy. We are primarily motivated by accelerated tumor repopulation towards the end of radiation…
Exploiting tumor shrinkage through temporal optimization of radiotherapy
Jan Unkelbach, David Craft, Theodore Hong +5
In multi-stage radiotherapy, a patient is treated in several stages separated by weeks or months. This regimen has been motivated mostly by radiobiological considerations, but also…
Averaging VMAT treatment plans for multi-criteria navigation
David Craft, David Papp, Jan Unkelbach
The main approach to smooth Pareto surface navigation for radiation therapy multi-criteria treatment planning involves taking real-time averages of pre-computed treatment plans. In…
Direct leaf trajectory optimization for volumetric modulated arc therapy planning with sliding window delivery
Dávid Papp, Jan Unkelbach
We propose a novel optimization model for volumetric modulated arc therapy (VMAT) planning that directly optimizes deliverable leaf trajectories in the treatment plan optimization…
Time--delay autosynchronization of the spatio-temporal dynamics in resonant tunneling diodes
J. Unkelbach, A. Amann, W. Just +1
The double barrier resonant tunneling diode exhibits complex spatio-temporal patterns including low-dimensional chaos when operated in an active external circuit. We demonstrate ho…