4 citations · 13 across the 6 of their papers we have counts for
6 papers
Kinetics of seeded protein aggregation: theory and application
Alexander J. Dear, Georg Meisl, Jing Hu +2
``Seeding'' is the addition of preformed fibrils to a solution of monomeric protein to accelerate its aggregation into new fibrils. It is a versatile and widely-used tool for scien…
General integrated rate law for complex self-assembly reactions reveals the mechanism of amyloid-beta co-aggregation
Alexander J. Dear, Georg Meisl, Emil Axell +5
Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyl…
Approximate Lie symmetries and singular perturbation theory
Alexander J. Dear, L. Mahadevan
Singular perturbation theory plays a central role in the approximate solution of nonlinear differential equations. However, applying these methods is a subtle art owing to the lack…
Mechanism, scaling and rates of protein aggregation from in vivo measurements
Georg Meisl, Alexander J Dear, Thomas CT Michaels +1
The formation and proliferation of protein aggregates play a central role in a number of devastating neuro-degenerative diseases. Many experimental studies indicate that the abilit…
Geometric localization in supported elastic struts
Thomas C. T. Michaels, Remy Kusters, Alexander J. Dear +3
Localized deformation patterns are a common motif in morphogenesis and are increasingly finding widespread applications in materials science, for instance as memory devices. Here w…
Effect of disorder on condensation in the lattice gas model on a random graph
Thomas P. Handford, Alexander Dear, Francisco J. Pérez-Reche +1
The lattice gas model of condensation in a heterogeneous pore system, represented by a random graph of cells, is studied using an exact analytical solution. A binary mixture of por…