3 papers
stat.ME2026
Gain-function optimisation of graphical multiple testing procedures for confirmatory clinical trials
Alexander D. V. Spiers, Michael J. Grayling, Graham M. Wheeler +1
Graphical multiple testing procedures are a flexible and transparent way to control the family-wise error rate when a confirmatory trial pursues several label claims, but they leav…
stat.AP2020
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs
Thomas Burnett, Pavel Mozgunov, Philip Pallmann +3
Adaptive designs for clinical trials permit alterations to a study in response to accumulating data in order to make trials more flexible, ethical and efficient. These benefits are…
stat.CO2019
A review of available software for adaptive clinical trial design
Michael J Grayling, Graham M Wheeler
Background/Aims: The increasing expense of the drug development process has seen interest in the use of adaptive designs (ADs) grow substantially in recent years. Accordingly, much…