187 citations · 273 across the 5 of their papers we have counts for
5 papers
Cellular tango: How extracellular matrix adhesion choreographs Rac-Rho signaling and cell movement
Elisabeth G. Rens, Leah Edelstein-Keshet
The small GTPases Rac and Rho are known to regulate eukaryotic cell shape, promoting front protrusion (Rac) or rear retraction (Rho) of the cell edge. Such cell deformation changes…
Spots, strips, and spiral waves in models for static and motile cells
Yue Liu, Elisabeth G. Rens, Leah Edelstein-Keshet
The polarization and motility of eukaryotic cells depends on assembly and contraction of the actin cytoskeleton and its regulation by proteins called GTPases. The activity of GTPas…
Cell Shape and Durotaxis Follow from Mechanical Cell-Substrate Reciprocity and Focal Adhesion Dynamics: A Unifying Mathematical Model
Elisabeth G. Rens, Roeland M. H. Merks
Many animal cells change their shape depending on the stiffness of the substrate on which they are cultured: they assume small, rounded shapes in soft ECMs, they elongate within st…
Cell contractility facilitates alignment of cells and tissues to static uniaxial stretch
Elisabeth G. Rens, Roeland M. H. Merks
During animal development and homeostasis, the structure of tissues, including muscles, blood vessels and connective tissues adapts to mechanical strains in the extracellular matri…
Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro
René F. M. van Oers, Elisabeth G. Rens, Danielle J. LaValley +2
In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an extr…