4 papers
A cross-study analysis of drug response prediction in cancer cell lines
Fangfang Xia, Jonathan Allen, Prasanna Balaprakash +21
To enable personalized cancer treatment, machine learning models have been developed to predict drug response as a function of tumor and drug features. However, most algorithm deve…
Evidence for a multi-level trophic organization of the human gut microbiome
Tong Wang, Akshit Goyal, Veronika Dubinkina +1
The human gut microbiome is a complex ecosystem, in which hundreds of microbial species and metabolites coexist, in part due to an extensive network of cross-feeding interactions.…
Multistability and regime shifts in microbial communities explained by competition for essential nutrients
Veronika Dubinkina, Yulia Fridman, Parth Pratim Pandey +1
Microbial communities routinely have several possible species compositions or community states observed for the same environmental parameters. Changes in these parameters can trigg…
Alternative stable states in a model of microbial community limited by multiple essential nutrients
Veronika Dubinkina, Yulia Fridman, Parth Pandey +1
Microbial communities routinely have several alternative stable states observed for the same environmental parameters. Sudden and irreversible transitions between these states make…