4 papers · 1 filter
Modeling the extracellular matrix in cell migration and morphogenesis: A guide for the curious biologist
Rebecca M. Crossley, Samuel Johnson, Erika Tsingos +8
The extracellular matrix (ECM) is a highly complex structure through which biochemical and mechanical signals are transmitted. In processes of cell migration, the ECM also acts as…
Cell-scale degradation of peritumoural extracellular matrix fibre network and its role within tissue-scale cancer invasion
Robyn Shuttleworth, Dumitru Trucu
Local cancer invasion of tissue is a complex, multiscale process which plays an essential role in tumour progression. Occurring over many different temporal and spatial scales, the…
Multiscale dynamics of a heterotypic cancer cell population within a fibrous extracellular matrix
Robyn Shuttleworth, Dumitru Trucu
Local cancer cell invasion is a complex process involving many cellular and tissue interactions and is an important prerequisite for metastatic spread, the main cause of cancer rel…
Multiscale Modelling of Fibres Dynamics and Cell Adhesion within Moving Boundary Cancer Invasion
Robyn Shuttleworth, Dumitru Trucu
Cancer cell invasion is recognised as one of the hallmarks of cancer and involves several inner-related multiscale processes that ultimately contribute to its spread into the surro…