3 papers
cond-mat.soft2021
Spontaneous Lipid Binding to the Nicotinic Acetylcholine Receptor in a Native Membrane
Liam Sharp, Grace Brannigan
The nicotinic acetylcholine receptor (nAChR) and other pentameric ligand-gated ion channels (pLGICs) are native to neuronal membranes with an unusual lipid composition. While it is…
physics.bio-ph2019
Untangling direct and domain-mediated interactions between nicotinic acetylcholine receptors in DHA-rich membranes
Kristen Woods, Liam Sharp, Grace Brannigan
At the neuromuscular junction (NMJ), the nicotinic acetylcholine receptor (nAChR) self-associates to give rise to rapid muscle movement. While lipid domains have maintained nAChR a…
q-bio.SC2018
Boundary lipids of the nicotinic acetylcholine receptor: spontaneous partitioning via coarse-grained molecular dynamics simulation
Liam Sharp, Reza Salari, Grace Brannigan
Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organ…