52 citations · 159 across the 15 of their papers we have counts for
18 papers
JASPR: Joint Spatial Representation learning of histology and spatial genomics for improved virtual genomic screening and clinical prognostication
Marija Pizurica, Eric Zimmermann, Neil Tenenholtz +5
Recent studies have shown that spatial properties of tumors are critical for understanding disease biology and predicting patient outcomes. These spatial properties are increasingl…
Multimodal Alignment Improves Generalizability of Genomic Biomarker Prediction in Computational Pathology
Ekaterina Redekop, Eric Zimmermann, Ava P Amini +5
Computational pathology models that use digitized histopathology whole-slide images have the potential to become a cost-effective and scalable alternative to molecular assays for t…
Mixed Magnification Aggregation for Generalizable Region-Level Representations in Computational Pathology
Eric Zimmermann, Julian Viret, Michal Zelechowski +7
In recent years, a standard computational pathology workflow has emerged where whole slide images are cropped into tiles, these tiles are processed using a foundation model, and ta…
PRISM2: Unlocking Multi-Modal General Pathology AI with Clinical Dialogue
Eugene Vorontsov, George Shaikovski, Adam Casson +16
Recent rapid progress in the field of computational pathology has been enabled by foundation models. These models are beginning to move beyond encoding image patches towards whole-…
Integrating chemical structures as treatments improves representations of microscopy images for morphological profiling
Yemin Yu, Emre Hayir, Neil Tenenholtz +5
Recent advances in self-supervised deep learning have improved our ability to quantify cellular morphological changes in high-throughput microscopy screens, a process known as morp…
Virchow2: Scaling Self-Supervised Mixed Magnification Models in Pathology
Eric Zimmermann, Eugene Vorontsov, Julian Viret +11
Foundation models are rapidly being developed for computational pathology applications. However, it remains an open question which factors are most important for downstream perform…
PRISM: A Multi-Modal Generative Foundation Model for Slide-Level Histopathology
George Shaikovski, Adam Casson, Kristen Severson +19
Foundation models in computational pathology promise to unlock the development of new clinical decision support systems and models for precision medicine. However, there is a misma…
Adapting Self-Supervised Learning for Computational Pathology
Eric Zimmermann, Neil Tenenholtz, James Hall +8
Self-supervised learning (SSL) has emerged as a key technique for training networks that can generalize well to diverse tasks without task-specific supervision. This property makes…
Tag-LLM: Repurposing General-Purpose LLMs for Specialized Domains
Junhong Shen, Neil Tenenholtz, James Brian Hall +2
Large Language Models (LLMs) have demonstrated remarkable proficiency in understanding and generating natural language. However, their capabilities wane in highly specialized domai…
RIDGE: Reproducibility, Integrity, Dependability, Generalizability, and Efficiency Assessment of Medical Image Segmentation Models
Farhad Maleki, Linda Moy, Reza Forghani +14
Deep learning techniques hold immense promise for advancing medical image analysis, particularly in tasks like image segmentation, where precise annotation of regions or volumes of…
Improving mitosis detection on histopathology images using large vision-language models
Ruiwen Ding, James Hall, Neil Tenenholtz +1
In certain types of cancerous tissue, mitotic count has been shown to be associated with tumor proliferation, poor prognosis, and therapeutic resistance. Due to the high inter-rate…
Should I Stop or Should I Go: Early Stopping with Heterogeneous Populations
Hammaad Adam, Fan Yin, Huibin +5
Randomized experiments often need to be stopped prematurely due to the treatment having an unintended harmful effect. Existing methods that determine when to stop an experiment ear…
Best Practices and Scoring System on Reviewing A.I. based Medical Imaging Papers: Part 1 Classification
Timothy L. Kline, Felipe Kitamura, Ian Pan +12
With the recent advances in A.I. methodologies and their application to medical imaging, there has been an explosion of related research programs utilizing these techniques to prod…
Initialization and Regularization of Factorized Neural Layers
Mikhail Khodak, Neil Tenenholtz, Lester Mackey +1
Factorized layers--operations parameterized by products of two or more matrices--occur in a variety of deep learning contexts, including compressed model training, certain types of…
DeepAAA: clinically applicable and generalizable detection of abdominal aortic aneurysm using deep learning
Jen-Tang Lu, Rupert Brooks, Stefan Hahn +9
We propose a deep learning-based technique for detection and quantification of abdominal aortic aneurysms (AAAs). The condition, which leads to more than 10,000 deaths per year in…
4D CNN for semantic segmentation of cardiac volumetric sequences
Andriy Myronenko, Dong Yang, Varun Buch +6
We propose a 4D convolutional neural network (CNN) for the segmentation of retrospective ECG-gated cardiac CT, a series of single-channel volumetric data over time. While only a sm…
Fully-Automated Analysis of Body Composition from CT in Cancer Patients Using Convolutional Neural Networks
Christopher P. Bridge, Michael Rosenthal, Bradley Wright +15
The amounts of muscle and fat in a person's body, known as body composition, are correlated with cancer risks, cancer survival, and cardiovascular risk. The current gold standard f…
Medical Image Synthesis for Data Augmentation and Anonymization using Generative Adversarial Networks
Hoo-Chang Shin, Neil A Tenenholtz, Jameson K Rogers +5
Data diversity is critical to success when training deep learning models. Medical imaging data sets are often imbalanced as pathologic findings are generally rare, which introduces…